A Comparative Study of Serum C-Reactive Proteins in Alcoholic and Infective Hepatitis Patients in Jodhpur (Rajasthan)

Introduction: C-reactive proteins (CRP) are a very good marker of inflammation and when the inflammation subsided, CRP quickly falls followed by erythrocyte sedimentation rate (ESR) thus it is a more sensitive and accurate reflection of the acute phase response than the ESR. As both alcoholic and infective hepatitis leads to inflammation in hepatocytes, CRP levels are increased in both conditions. Material and Method: The present study was conducted on 200 each patients of both alcoholic and infective hepatitis in Department of Biochemistry, Dr. S. N. Medical College, Jodhpur and the results were compared with 100 healthy control subjects. The serum CRP levels were measured by turbidimetry immunoassay method. Result and Discussion: The mean serum C-reactive protein of the healthy control was 0.232 ±0.18 mg/dL; for alcoholic hepatitis patients mean serum C-reactive protein was 27.01± 12.26 mg/dL while in infective hepatitis subjects, the observed mean serum C-reactive protein was 27.56 ± 12.32 mg/dL Both alcoholic and infective hepatitis patients showed a highly significant relationship when compared with healthy control subjects. Conclusion: Estimation of CRP is simple, quick and reliable so it should be included in the routine investigations of alcoholic as well as infective hepatitis patients for better management and prognosis of disease.